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- Samvera; Repository Framework
- Scalar
- ScienceOpen
- Scinapse
- SciPost, publication portal
- Scite plugin
- SEEK platform, sharing heterogeneous scientific research datasets, models or simulations.
- Semantic Scholar
- Share
- Social Science Reproduction Platform (SSRP)
- Sourcery, web-based application for providing remote access to archival documents
- SSH Open Marketplace
- Stencila
T
- TagTeam
- Tainacan
- Telemeta, collaborative media asset management system for musicology
- TemaTres
- Textbooks for Pressbooks
- Texture
- The Datahub
- The Hybrid Lecture Player
- The LENS Platform
- The Readium Foundation
- The Studio’s Notebooks
- Thoth
- TIB Open Publishing
- TimeMapper
- Tropy – Research Photo Manegement
- Typademic, an academic publishing pipeline